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pentobarbital will minimize the level or effect of colchicine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.Barbiturates can induce hepatic microsomal enzymes causing improved metabolism and diminished anticoagulant response of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); people stab